Open AccessA CLONAL ANALYSIS OF DETERMINATION IN Antennapedia , A HOMOEOTIC MUTANT OF Drosophila melanogaster
Author(s) -
John H. Postlethwait,
Howard A. Schneiderman
Publication year - 1969
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.64.1.176
Subject(s) - drosophila melanogaster , biology , antennapedia , somatic cell , genetics , population , mutant , instar , mutation , clone (java method) , larva , dna , botany , gene , medicine , environmental health , homeotic gene
The process by which cells select one of several specific programs of genetic information in development was examined in homoeotic mutant Antennapedia of Rappaport in Drosophila melanogaster. The results show that the alteration of determination from antenna to leg induced by this homoeotic mutation occurs in a population of cells related by proximity rather than by pedigree. Clones of cells marked by means of X-ray-induced somatic crossing-over prior to early third instar participated in the formation of both antenna and homoeotic leg, but after this time, the clone was restricted to either antenna or homoeotic leg, indicating that determination occurs in the third larval instar. The results are discussed in relation to other processes of determination.