INCREASE IN RAT BRAIN TYROSINE HYDROXYLASE ACTIVITY PRODUCED BY ELECTROCONVULSIVE SHOCK | Zendy

José M. Musacchio | Zendy; L Julou | Zendy; Seymour S. Kety | Zendy; Jacques Glowinski | Zendy

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INCREASE IN RAT BRAIN TYROSINE HYDROXYLASE ACTIVITY PRODUCED BY ELECTROCONVULSIVE SHOCK

Author(s) -

José M. Musacchio,

L Julou,

Seymour S. Kety,

Jacques Glowinski

Publication year - 1969

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.63.4.1117

Subject(s) - tyrosine hydroxylase , norepinephrine , electroconvulsive shock , medicine , tyrosine , endocrinology , brainstem , chemistry , shock (circulatory) , dopamine , striatum , enzyme assay , cerebral cortex , enzyme , biology , biochemistry

A sustained increase in the turnover of norepinephrine coupled with an increased concentration of that amine has, in a previous study, been observed in the brains of rats exposed to electroconvulsive shock twice daily for one week. The phenomenon has been further examined by studying the effects of a similar regimen of electroconvulsive shock upon tyrosine hydroxylase in the brain, since that enzyme appears to be rate-limiting in norepinephrine synthesis. A small (15%) but significant increase in the whole brain enzyme activity was found in the electroshock-treated animals. A significant increase of tyrosine hydroxylase activity was found in the brainstem (24%) and cortex (20%) of such animals.

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