AMINO ACID SEQUENCE RESTRICTION IN RABBIT ANTIBODY LIGHT CHAINS | Zendy

Leroy Hood | Zendy; Henry Lackland | Zendy; Klaus Eichman | Zendy; Thomas J. Kindt | Zendy; Dietmar G. Braun | Zendy; Richard M. Krause | Zendy

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AMINO ACID SEQUENCE RESTRICTION IN RABBIT ANTIBODY LIGHT CHAINS

Author(s) -

Leroy Hood,

Henry Lackland,

Klaus Eichman,

Thomas J. Kindt,

Dietmar G. Braun,

Richard M. Krause

Publication year - 1969

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.63.3.890

Subject(s) - immunoglobulin light chain , antibody , peptide sequence , amino acid , biology , rabbit (cipher) , sequence (biology) , biochemistry , amino acid residue , microbiology and biotechnology , chemistry , genetics , gene , statistics , mathematics

Light chains were obtained from IgG rabbit antibodies to the group-specific carbohydrates of groups A and C streptococci. An analysis of the amino acid alternatives which exist at the first three positions of the N-terminus in both light-chain preparations shows a marked restriction in amino acid sequence heterogeneity when compared with preimmune light chains. Both of these related, but immunologically distinct, antigenic determinants select the same uncommon subpopulation of rabbit light chains.

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