Open AccessON THE CONFORMATIONAL INSTABILITY OF HUMAN SERUM LOW-DENSITY LIPOPROTEIN: EFFECT OF TEMPERATURE
Author(s) -
Angelo M. Scanu,
Harvey B. Pollard,
R. Hirz,
K. Kothary
Publication year - 1969
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.62.1.171
Subject(s) - circular dichroism , chemistry , lipoprotein , low density lipoprotein , apolipoprotein b , biochemistry , cholesterol
When examined by circular dichroism and ultraviolet spectroscopy, human serum low-density lipoprotein (LDL) and its delipidated product, apo LDL, exhibited reversible thermal changes. The more marked temperature sensitivity of apo LDL as compared to LDL was taken to support a constraining role by lipids on the observed structural instability of the apoprotein.