Open AccessCryo-EM structures of cancer-specific helical and kinase domain mutations of PI3Kα
Author(s) -
Xiao Liu,
Qingtong Zhou,
Jonathan R. Hart,
Yingna Xu,
Yang Su,
Dehua Yang,
Peter K. Vogt,
Mingwei Wang
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2215621119
Subject(s) - p110α , protein subunit , mutant , kinase , phosphoinositide 3 kinase , chemistry , protein kinase domain , microbiology and biotechnology , mutation , signal transduction , biology , pi3k/akt/mtor pathway , biochemistry , gene