Open AccessCryo-EM structures of cancer-specific helical and kinase domain mutations of PI3Kα
Author(s) -
Xiao Liu,
Qingtong Zhou,
Jonathan R. Hart,
Yingna Xu,
Su Yang,
Dehua Yang,
Peter K. Vogt,
MingWei Wang
Publication year - 2022
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2215621119
Subject(s) - p110α , protein subunit , mutant , kinase , chemistry , phosphoinositide 3 kinase , protein kinase domain , mutation , microbiology and biotechnology , signal transduction , pi3k/akt/mtor pathway , biochemistry , biology , gene
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