Open AccessEvolution avoids a pathological stabilizing interaction in the immune protein S100A9
Author(s) -
Joseph Harman,
Patrick N. Reardon,
Shawn M. Costello,
Gus D Warren,
Sophia R. Phillips,
Patrick Connor,
Susan Marqusee,
Michael J. Harms
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2208029119
Subject(s) - mutant , mutation , protein structure , denaturation (fissile materials) , protein engineering , biophysics , function (biology) , biology , chemistry , microbiology and biotechnology , biochemistry , gene , enzyme , nuclear chemistry