Open AccessQuantitative NMR analysis of the kinetics of prenucleation oligomerization and aggregation of pathogenic huntingtin exon-1 protein
Author(s) -
Alberto Ceccon,
Vitali Tugarinov,
Francesco Torricella,
G. Marius Clore
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2207690119
Subject(s) - kinetics , chemistry , biophysics , microsecond , crystallography , dimer , protein aggregation , fibril , oligomer , nucleation , heteronuclear molecule , folding (dsp implementation) , huntingtin protein , huntingtin , nuclear magnetic resonance spectroscopy , stereochemistry , biochemistry , mutant , biology , physics , organic chemistry , quantum mechanics , astronomy , gene , electrical engineering , engineering