Open AccessInhibition of RAS-driven signaling and tumorigenesis with a pan-RAS monobody targeting the Switch I/II pocket
Author(s) -
Lauren Wallon,
Imran Khan,
Kai Wen Teng,
Akiko Koide,
Mariyam Zuberi,
Jianping Li,
Gayatri Ketavarapu,
Nathaniel J. Traaseth,
John P. O’Bryan,
Shohei Koide
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2204481119
Subject(s) - kras , druggability , small molecule , carcinogenesis , in vivo , cancer research , biology , mutant , gene isoform , chemistry , mutation , microbiology and biotechnology , biochemistry , cancer , genetics , gene