Open AccessOncogenic β-catenin stimulation of AKT2–CAD-mediated pyrimidine synthesis is targetable vulnerability in liver cancer
Author(s) -
Fangming Liu,
Xiaochen Gai,
Yuting Wu,
Baohui Zhang,
Xiaoyu Wu,
Rong-Rong Cheng,
Bufu Tang,
Kezhuo Shang,
Na Zhao,
Weiwei Deng,
Jie Chen,
Zhengyi Zhang,
Song Gu,
Lirong Zheng,
Hongbing Zhang
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2202157119
Subject(s) - pyrimidine metabolism , biology , cancer research , catenin , wnt signaling pathway , carcinogenesis , druggability , cancer , microbiology and biotechnology , biochemistry , signal transduction , enzyme , genetics , gene , purine