Open AccessOncogenic β-catenin stimulation of AKT2–CAD-mediated pyrimidine synthesis is targetable vulnerability in liver cancer
Author(s) -
Fangming Liu,
Xiaochen Gai,
Yuting Wu,
Baohui Zhang,
Xiaoyu Wu,
Rongrong Cheng,
Bufu Tang,
Kezhuo Shang,
Na Zhao,
WeiWei Deng,
Jie Chen,
Zhengyi Zhang,
Song Gu,
Liang Zheng,
Hongbing Zhang
Publication year - 2022
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2202157119
Subject(s) - pyrimidine metabolism , biology , cancer research , wnt signaling pathway , carcinogenesis , catenin , druggability , akt2 , cancer , microbiology and biotechnology , signal transduction , biochemistry , akt1 , enzyme , genetics , protein kinase b , gene , purine
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