Open AccessBrap regulates liver morphology and hepatocyte turnover via modulation of the Hippo pathway
Author(s) -
Christina Priest,
Rohith T. Nagari,
Lara Bideyan,
Stephen D. Lee,
Alexander Nguyen,
Xiao Xu,
Peter Tontonoz
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2201859119
Subject(s) - microbiology and biotechnology , hepatocyte , ubiquitin ligase , biology , function (biology) , hippo signaling pathway , inflammation , liver disease , extracellular , ubiquitin , cancer research , gene , signal transduction , immunology , genetics , biochemistry , in vitro
Significance The liver has a complex cellular architecture that is essential for its function. In this work, we show that BRAP, a ubiquitin ligase of poorly understood function, is required for maintenance of proper liver morphology. BRAP deletion in the liver causes disruption of its normal architecture and inflammation due to altered expression of genes involved in cell growth and extracellular interactions. This work sheds light on the mechanisms that maintain proper liver structure and has implications for liver disease.