Open AccessAcat1/Soat1 knockout extends the mutant Npc1 mouse lifespan and ameliorates functional deficiencies in multiple organelles of mutant cells
Author(s) -
Maximillian A. Rogers,
Catherine C.Y. Chang,
Robert A. Maue,
Elaina M. Melton,
Andrew A. Peden,
William S. Garver,
Junghoon Lee,
Peter W. Schroen,
Mitchell M. Huang,
TaYuan Chang
Publication year - 2022
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2201646119
Subject(s) - npc1 , endosome , golgi apparatus , microbiology and biotechnology , endoplasmic reticulum , biology , sterol o acyltransferase , lysosome , cholesterol , lipid droplet , biochemistry , enzyme , intracellular , lipoprotein
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