Open AccessThe effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis
Author(s) -
Nicolas Guthertz,
Rob van der Kant,
R. M. Martinez,
Yong Xu,
Chi H. Trinh,
Bogdan I. Iorga,
Frédéric Rousseau,
Joost Schymkowitz,
David J. Brockwell,
Sheena E. Radford
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2200468119
Subject(s) - protein aggregation , in silico , in vitro , in vivo , chemistry , mutagenesis , amino acid , saturated mutagenesis , biochemistry , protein structure , amyloid (mycology) , point mutation , protein folding , biophysics , mutation , biology , mutant , genetics , gene , inorganic chemistry