Open AccessPathogen-induced biosynthetic pathways encode defense-related molecules in bread wheat
Author(s) -
Guy Polturak,
Martin Dippe,
Michael J. Stephenson,
Rajesh Chandra Misra,
Charlie Owen,
Ricardo H. Ramírez-González,
John F Haidoulis,
Henkjan Schoonbeek,
Laëtitia Chartrain,
Philippa Borrill,
David R. Nelson,
J. K. M. Brown,
P. Nicholson,
Cristóbal Uauy,
Anne Osbourn
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2123299119
Subject(s) - brachypodium distachyon , biology , genome , gene , transcriptome , plant defense against herbivory , plant disease resistance , computational biology , biotic stress , pathogen , brachypodium , genomics , functional genomics , encode , genetics , gene cluster , abiotic stress , gene expression
Significance Wheat is a globally important food crop that suffers major yield losses due to outbreaks of severe disease. A better mechanistic understanding of how wheat responds to pathogen attack could identify new strategies for enhancing disease resistance. Here, we discover six pathogen-induced biosynthetic pathways that share a common regulatory network and form part of an orchestrated defense response. Investigation of the wheat genome reveals that these pathways are each encoded by biosynthetic gene clusters (BGCs). We further show that these BGCs produce flavonoids and terpenes that may serve as phytoalexins or defense-related signaling molecules. Our results provide key insights into the molecular basis of biotic stress responses in wheat and open potential avenues for crop improvement.