Open AccessIntegrative analysis reveals multiple modes of LXR transcriptional regulation in liver
Author(s) -
Lara Bideyan,
Fan Wang,
Karolina Elżbieta KaczorUrbanowicz,
Christina Priest,
David Casero,
Peter Tontonoz
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2122683119
Subject(s) - liver x receptor , nuclear receptor , chromatin , biology , transcription factor , promoter , chromatin immunoprecipitation , regulation of gene expression , activator (genetics) , transcriptional regulation , microbiology and biotechnology , gene expression , gene , genetics
Significance LXRs are critical regulators of hepatic metabolism and function, but their mechanisms of action at the genome level are incompletely understood. We performed integrated analysis of genome-wide chromatin accessibility, gene expression, and transcription factor binding. We reveal distinct mechanisms of LXR transcriptional regulation of both metabolic and nonmetabolic genes in liver. We show that LXR can both activate and repress genes and that LXR binding impacts the activity of other transcription factors.