Inhibitors of PARP: Number crunching and structure gazing | Zendy

Johannes Rudolph | Zendy; Karen Jung | Zendy; Karolin Luger | Zendy

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Inhibitors of PARP: Number crunching and structure gazing

Author(s) -

Johannes Rudolph,

Karen Jung,

Karolin Luger

Publication year - 2022

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.2121979119

Subject(s) - poly adp ribose polymerase , computer science , computational biology , biology , genetics , dna , polymerase

Significance PARP is an important target in the treatment of cancers, particularly in patients with breast, ovarian, or prostate cancer that have compromised homologous recombination repair (i.e., BRCA−/− ). This review about inhibitors of PARP (PARPi) is for readers interested in the development of next-generation drugs for the treatment of cancer, providing insights into structure–activity relationships, in vitro vs. in vivo potency, PARP trapping, and synthetic lethality.

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