Open AccessFunctional network topography of the medial entorhinal cortex
Author(s) -
Horst A. Obenhaus,
Weijian Zong,
R. Irene Jacobsen,
Tobias Rose,
Flavio Donato,
Liangyi Chen,
Heping Cheng,
Tobias Bonhoeffer,
MayBritt Moser,
Edvard I Moser
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2121655119
Subject(s) - grid cell , entorhinal cortex , neuroscience , coupling (piping) , electrophysiology , cell type , anatomy , border cells , biology , grid , hippocampus , cell , geography , materials science , genetics , geodesy , metallurgy
Significance The investigation of the topographic organization of spatially coding cell types in the medial entorhinal cortex (MEC) has so far been held back by the lack of appropriate tools that enable the precise recording of both the anatomical location and activity of large populations of cells while animals forage in open environments. In this study, we use the newest generation of head-mounted, miniaturized two-photon microscopes to image grid, head-direction, border, as well as object-vector cells in MEC and neighboring parasubiculum within the same animals. The majority of cell types were intermingled, but grid and object-vector cells exhibited little overlap. The results have implications for network models of spatial coding.