A commensal-encoded genotoxin drives restriction of Vibrio cholerae colonization and host gut microbiome remodeling | Zendy

Jiandong Chen | Zendy; Hyuntae Byun | Zendy; Rui Liu | Zendy; I-Ji Jung | Zendy; Qinqin Pu | Zendy; Clara Y. Zhu | Zendy; Ethan Tanchoco | Zendy; Salma Alavi | Zendy; Patrick H. Degnan | Zendy; Amy T. | Zendy; Manuela Roggiani | Zendy; Joris Beld | Zendy; Mark Goulian | Zendy; Ansel Hsiao | Zendy; Jun Zhu | Zendy

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A commensal-encoded genotoxin drives restriction of Vibrio cholerae colonization and host gut microbiome remodeling

Author(s) -

Jiandong Chen,

Hyuntae Byun,

Rui Liu,

I-Ji Jung,

Qinqin Pu,

Clara Y. Zhu,

Ethan Tanchoco,

Salma Alavi,

Patrick H. Degnan,

Amy T.,

Manuela Roggiani,

Joris Beld,

Mark Goulian,

Ansel Hsiao,

Jun Zhu

Publication year - 2022

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.2121180119

Subject(s) - colonization , biology , microbiome , vibrio cholerae , colonisation resistance , microbiology and biotechnology , host (biology) , colonisation , symbiosis , commensalism , niche , dysbiosis , bacteria , ecology , genetics

Significance In a polymicrobial battlefield where different species compete for nutrients and colonization niches, antimicrobial compounds are the sword and shield of commensal microbes in competition with invading pathogens and each other. The identification of anEscherichia coli –produced genotoxin, colibactin, and its specific targeted killing of enteric pathogens and commensals, includingVibrio cholerae andBacteroides fragilis , sheds light on our understanding of intermicrobial interactions in the mammalian gut. Our findings elucidate the mechanisms through which genotoxins shape microbial communities and provide a platform for probing the larger role of enteric multibacterial interactions regarding infection and disease outcomes.

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