Open AccessA commensal-encoded genotoxin drives restriction of Vibrio cholerae colonization and host gut microbiome remodeling
Author(s) -
Jiandong Chen,
Hyuntae Byun,
Rui Li,
I-Ji Jung,
Qinqin Pu,
Clara Y. Zhu,
Ethan Tanchoco,
Salma Alavi,
Patrick H. Degnan,
Amy T.,
Manuela Roggiani,
Joris Beld,
Mark Goulian,
Ansel Hsiao,
Jun Zhu
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2121180119
Subject(s) - vibrio cholerae , biology , microbiology and biotechnology , colonization , microbiome , bacteroides fragilis , commensalism , host (biology) , escherichia coli , colonisation resistance , vibrio , bacteria , genetics , gene , antibiotics
Significance In a polymicrobial battlefield where different species compete for nutrients and colonization niches, antimicrobial compounds are the sword and shield of commensal microbes in competition with invading pathogens and each other. The identification of anEscherichia coli –produced genotoxin, colibactin, and its specific targeted killing of enteric pathogens and commensals, includingVibrio cholerae andBacteroides fragilis , sheds light on our understanding of intermicrobial interactions in the mammalian gut. Our findings elucidate the mechanisms through which genotoxins shape microbial communities and provide a platform for probing the larger role of enteric multibacterial interactions regarding infection and disease outcomes.