Open AccessTranscriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases
Author(s) -
Yuting Dai,
Fan Zhang,
Hai Fang,
Jianfeng Li,
Gang Lu,
Lu Jiang,
Bing Chen,
Dongdong Mao,
Yuanfang Liu,
Jin Wang,
Lijun Peng,
Chong Feng,
Haifeng Chen,
Junxi Mu,
Qunling Zhang,
Hao Wang,
Hany Ariffin,
Tan Ah Moy,
Jinghan Wang,
Yinjun Lou,
Suning Chen,
Qian Wang,
Hong Liu,
Zhe Shan,
Itaru Matsumura,
Yasushi Miyazaki,
Takahiko Yasuda,
Liping Dou,
Xiaojing Yan,
Jinsong Yan,
Allen Eng-Juh Yeoh,
Depei Wu,
Hitoshi Kiyoi,
Fumihiko Hayakawa,
Jie Jin,
Shengyue Wang,
Xiao Jian Sun,
Jian-Qing Mi,
Jinyan Huang,
SaiJuan Chen
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2120787119
Subject(s) - biology , progenitor cell , epigenetics , transcriptome , cancer research , phenotype , leukemia , zebrafish , gene , immunology , stem cell , genetics , gene expression
Significance We provide transcriptomic insights into differences between pediatric and adult T cell acute lymphoblastic leukemia (T-ALL) patients through an international collaborative effort integrating RNA-sequencing data of 707 patients. Ten subtypes were identified, each characterized by distinct gene mutation profiles and dysregulated expression signatures of leukemogenic factors, and associated with T cell development stages. Adult T-ALL tends to have characteristics of early T cell precursor ALL, mostly corresponding to the mixed phenotype acute leukemia, whereas pediatric T-ALL shows a wide spectrum of aberrant molecular features, from early T cell precursor to mature T cell compartments. Our findings have important implications for disease mechanism of T-ALL that differs between pediatric and adult patients, facilitating further refined targeted therapy.