Open AccessCell size and polarization determine cytokinesis furrow ingression dynamics in mouse embryos
Author(s) -
Lia Mara Gomes Paim,
Greg FitzHarris
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2119381119
Subject(s) - ingression , cytokinesis , cleavage furrow , microbiology and biotechnology , biology , cell division , cell polarity , apical constriction , cytoplasm , cell , morphogenesis , genetics , gene
Significance The final step of cell division, termed cytokinesis, comprises the constriction of a furrow that divides the cytoplasm to form two daughter cells. Although cytokinesis is well studied in traditional cell systems, how cytokinesis is regulated in complex multicellular settings and during cell-fate decisions is less well understood. Here, using live imaging and physical and molecular interventions, we find that the emergence of cell polarity during mouse embryo morphogenesis dramatically impacts cytokinesis mechanisms. Specifically, the assembly of the apical domain in outer cells locally inhibits the cytokinetic machinery, leading to an unexpected laterally biased cytokinesis.