Open AccessMembers of the KCTD family are major regulators of cAMP signaling
Author(s) -
Brian S. Muntean,
Subhi Marwari,
Xiaona Li,
Douglas C. Sloan,
Brian Young,
James A. Wohlschlegel,
Kirill A. Martemyanov
Publication year - 2021
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2119237119
Subject(s) - g protein coupled receptor , allosteric regulation , second messenger system , microbiology and biotechnology , biology , cyclic adenosine monophosphate , adenylyl cyclase , signal transduction , g protein , gs alpha subunit , gene isoform , potassium channel , receptor , biochemistry , gene , endocrinology
Significance Neuromodulation is pivotal for brain function. One of the key pathways engaged by neuromodulators is signaling via second messenger cAMP, which controls a myriad of fundamental reactions. This study identifies KCTD5, a ubiquitin ligase adapter, as a regulatory element in this pathway and determines that it works by an unusual dual mode controlling the activity of cAMP-generating enzyme in neurons through both zinc transport and G protein signaling.