Open AccessCa 2+ leak through ryanodine receptor 1 regulates thermogenesis in resting skeletal muscle
Author(s) -
Aldo Meizoso-Huesca,
Luke Pearce,
Christopher John Barclay,
Bradley S. Launikonis
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2119203119
Subject(s) - ryr1 , ryanodine receptor , skeletal muscle , thermogenesis , endoplasmic reticulum , medicine , biophysics , chemistry , dantrolene , malignant hyperthermia , biology , endocrinology , microbiology and biotechnology , calcium , anesthesia , obesity
Significance The evolution of mammals to use skeletal muscle as a source of heat allowed them to spread to all parts of the globe. The generation of heat requires increased adenosine triphosphate (ATP) hydrolysis in the resting muscle in a regulated manner, but how this mechanism works is unknown. The results suggest that mammals increase their RyR1 Ca2+ leak rate to amplify a basal ATP turnover rate at the sarcoplasmic reticulum Ca2+ pump that is higher than that of lower vertebrates. Muscle-based thermogenesis allows regulation of body temperature that is essential for life in mammals and provides a potential pathway for manipulating body weight or temperature by altering metabolic rate.