Open AccessInjury-induced inflammatory signaling and hematopoiesis in Drosophila
Author(s) -
Cory J. Evans,
Ting Liu,
Juliet R. Girard,
Utpal Banerjee
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2119109119
Subject(s) - microbiology and biotechnology , biology , proinflammatory cytokine , signal transduction , immunology , haematopoiesis , innate immune system , toll like receptor , inflammation , immune system , stem cell
Significance We explore mechanisms by which stress caused by acute injury affects blood cell development and inflammatory response inDrosophila . Similar to their mammalian myeloid counterparts, these cells are predisposed to sense and react to sterile injury at distant sites. Upon sterile injury, a breach of epidermis sets up a reactive oxygen species-based signal that bypasses the pathogen-sensing apparatus of septic immune challenge, but merges downstream to activate Toll. A number of autonomous and nonautonomous signaling pathways follow in a sequence and are mapped temporally by the appearance of their corresponding molecular phenotypes. A cell-type that fights deposited parasitic wasp eggs appears with sterile injury without the immune challenge, perhaps in anticipation, because in nature injury is usually followed by infection.