Open AccessDual-function AzuCR RNA modulates carbon metabolism
Author(s) -
Medha Raina,
Jordan J. Aoyama,
Shantanu Bhatt,
Brian J. Paul,
Aixia Zhang,
Taylor B. Updegrove,
Juan Miranda-Ríos,
Gisela Storz
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2117930119
Subject(s) - rna , biochemistry , base pair , nucleotide , biology , function (biology) , amino acid , nucleic acid , non coding rna , microbiology and biotechnology , gene , chemistry
Significance While most small, regulatory RNAs are thought to be “noncoding,” a few have been found to also encode a small protein. Here we describe a 164-nucleotide RNA that encodes a 28-amino acid, amphipathic protein, which interacts with aerobic glycerol-3-phosphate dehydrogenase and increases dehydrogenase activity but also base pairs with two mRNAs to reduce expression. The coding and base-pairing sequences overlap, and the two regulatory functions compete.