Open AccessThe gut microbiome influences host diet selection behavior
Author(s) -
Brian K. Trevelline,
Kevin D. Kohl
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2117537119
Subject(s) - biology , omnivore , microbiome , gut flora , tryptophan , foraging , carnivore , host (biology) , herbivore , gut microbiome , amino acid , zoology , genetics , ecology , biochemistry , predation
Significance The behavior of diet selection or diet choice can have wide-reaching implications, scaling from individual animals to ecological and evolutionary processes. Previous work in this area has largely ignored the potential for intestinal microbiota to modulate host foraging decisions. The notion that the gut microbiome may influence host foraging behavior has been highly speculated for years but has not yet been explicitly tested. Here, we show that germ-free mice colonized by differential microbiomes from wild rodents with varying natural feeding strategies exhibited significant differences in their voluntary dietary selection. Specifically, colonized mice differed in voluntary carbohydrate selection, and divergent feeding preferences were associated with differences in circulating essential amino acids, bacterial tryptophan metabolism, and intestinal morphology. Together, these results demonstrate a role for the microbiome in host nutritional physiology and foraging behavior.