Open AccessReversible dougong structured receptor–ligand recognition for building dynamic extracellular matrix mimics
Author(s) -
Wenbo He,
Jiaxiang Bai,
Chunxiang Xu,
Di Suo,
Shenghao Wang,
Qi Guo,
Wang Yin,
Miao Wang,
Guoqing Pan,
Xin Zhao,
Bin Li
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2117221119
Subject(s) - extracellular matrix , scaffold , biomaterial , biointerface , chemistry , nanotechnology , molecular recognition , ligand (biochemistry) , matrix (chemical analysis) , dipeptide , biophysics , computational biology , computer science , materials science , receptor , biochemistry , biomedical engineering , engineering , peptide , biology , molecule , organic chemistry , chromatography
Significance This paper reports an exciting breakthrough in dynamic biomaterials design mimicking the reversible interlocking and remoldable structure of extracellular matrix (ECM). Specifically, we realize a nature-derived molecular recognition event (i.e., the antibiotic glycopeptide vancomycin [Van] and the dipeptided -Ala-d -Ala [AA] receptor–ligand interaction) as a reversible strategy for fabrication of dynamic biointerface and 3D ECM mimics. We believe that the specific but reversible Van–AA molecular recognition would be a strategy for dynamic biomaterial fabrication, and that the easy-handling merit, ECM-like remoldability, and inherent antibacterial activity will bring insights to biomaterial scaffold design in tissue engineering and regenerative medicine.