Histone methylation-mediated microRNA-32-5p down-regulation in sensory neurons regulates pain behaviors via targeting Cav3.2 channels | Zendy

Renfei Qi | Zendy; Junping Cao | Zendy; Yufang Sun | Zendy; Yanping Li | Zendy; Zitong Huang | Zendy; Dongsheng Jiang | Zendy; Xinghong Jiang | Zendy; Terrance P. Snutch | Zendy; Yuan Zhang | Zendy; Jin Tao | Zendy

Open Access

Histone methylation-mediated microRNA-32-5p down-regulation in sensory neurons regulates pain behaviors via targeting Cav3.2 channels

Author(s) -

Renfei Qi,

Junping Cao,

Yufang Sun,

Yanping Li,

Zitong Huang,

Dongsheng Jiang,

Xinghong Jiang,

Terrance P. Snutch,

Yuan Zhang,

Jin Tao

Publication year - 2022

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.2117209119

Subject(s) - microrna , neuropathic pain , histone , epigenetics , nociception , neuroscience , regulation of gene expression , chronic pain , dna methylation , medicine , gene expression , bioinformatics , gene , biology , receptor , genetics

Significance In this study, we identify microRNA-32-5p (miR-32-5p) as a key functional noncoding RNA in trigeminal-mediated neuropathic pain. We report that injury-induced histone methylation attenuates the binding of glucocorticoid receptor to the promoter region of themiR-32-5p gene and decreases the expression of miR-32-5p, in turn promoting the development of neuropathic pain through regulation of Cav3.2 channels. miRNA-mediated gene regulation has been proposed as a therapeutic approach in neuropathic pain. Our findings identify miR-32-5p replenishment as a therapeutic strategy for treating chronic neuropathic pain.

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