Open AccessLong-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis
Author(s) -
Shuai Zhang,
Ornella D. Nelson,
Ian R. Price,
Chengliang Zhu,
Xuan Lü,
Irma Fernández,
Robert S. Weiss,
Hening Lin
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2117013119
Subject(s) - metastasis , cancer , function (biology) , biochemistry , mechanism (biology) , coenzyme a , fatty acid , fatty acid metabolism , cancer metastasis , biology , chemistry , cancer research , microbiology and biotechnology , enzyme , genetics , reductase , philosophy , epistemology
Significance The study provided a long-sought molecular mechanism that could explain the link between fatty acid metabolism and cancer metastasis. Further understanding may lead to new strategies to inhibit cancer metastasis. The chemical proteomic approach developed here will be useful for discovering other regulatory mechanisms of protein function by small molecule metabolites.