Open AccessHYL1-CLEAVAGE SUBTILASE 1 (HCS1) suppresses miRNA biogenesis in response to light-to-dark transition
Author(s) -
Hyun Ju Jung,
Sukwon Choi,
Kyung-Hwan Boo,
JeeEun Kim,
Young Kyoung Oh,
Min Seok Han,
Moon Young Ryu,
Chang Woo Lee,
Christian Møller,
Pratik Shah,
Gu Min Kim,
Woorim Yang,
Seok Keun Cho,
Seong Wook Yang
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2116757119
Subject(s) - biogenesis , microbiology and biotechnology , mutant , cytoplasm , biology , arabidopsis , chemistry , genetics , gene
Significance HYPONASTIC LEAVES 1 (HYL1)-CLEAVAGE SUBTILASE 1 (HCS1) is a novel negative regulator of microRNA (miRNA) biogenesis that degrades HYL1 in the cytoplasm. Furthermore, cytoplasm CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) E3 ligase inhibit HCS1-mediated HYL1 degradation. The COP1-HYL1-HCS1 network may integrate two essential cellular pathways: the miRNA-biogenetic pathway and light signaling pathway. Our finding suggests a regulatory pathway in the miRNA-biogenetic system.