Open AccessC-type natriuretic peptide is a pivotal regulator of metabolic homeostasis
Author(s) -
Cristina PérezTernero,
Aisah A. Aubdool,
Raj Makwana,
Gareth J. Sanger,
Roland H Stimson,
Li Chan,
Amie J Moyes,
Adrian J. Hobbs
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2116470119
Subject(s) - adipogenesis , glucose homeostasis , endocrinology , medicine , energy homeostasis , biology , homeostasis , natriuretic peptide , thermogenesis , adipose tissue , insulin , insulin resistance , heart failure , obesity
Significance The global mortality, morbidity, and healthcare costs associated with cardiometabolic disease, including obesity, diabetes, hypertension, and dyslipidemia, are substantial and represent an expanding unmet medical need. Herein, we have identified a physiological role for C-type natriuretic peptide (CNP) in regulating key processes, including thermogenesis and adipogenesis, which combine to coordinate metabolic function and prevent the development of cardiometabolic disorders. This protective mechanism, which is in part mediated via an autocrine action of CNP on adipocytes, is underpinned by activation of cognate natriuretic peptide receptors (NPR)-B and NPR-C. This mechanism advances the fundamental understanding of energy homeostasis and glucose handling and offers the promise of improving the treatment of cardiometabolic disease.