The major genetic risk factor for severe COVID-19 is associated with protection against HIV | Zendy

Hugo Zeberg | Zendy

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The major genetic risk factor for severe COVID-19 is associated with protection against HIV

Author(s) -

Hugo Zeberg

Publication year - 2022

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.2116435119

Subject(s) - covid-19 , haplotype , risk factor , biology , genetics , virology , medicine , genotype , gene , disease , outbreak , infectious disease (medical specialty)

There are genetic risk factors that influence the outcome of COVID-19 [COVID-19 Host Genetics Initiative,Nature 600, 472–477 (2021)]. The major genetic risk factor for severe COIVD-19 resides on chromosome 3 and is inherited from Neandertals [H. Zeberg, S. Pääbo,Nature 587, 610–612 (2020)]. The risk-associated DNA segment modulates the expression of several chemokine receptors, among them CCR5, a coreceptor for HIV which is down-regulated in carriers of the COVID-19 risk haplotype. Here I show that carriers of the risk variant have an ∼27% lower risk of HIV infection.

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