Open AccessA microfluidic device for real-time on-demand intravenous oxygen delivery
Author(s) -
Ashwin Kumar Vutha,
Ryan Patenaude,
Alexis R. Cole,
Rajesh Kumar,
John N. Kheir,
Brian D. Polizzotti
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2115276119
Subject(s) - hypoxemia , refractory (planetary science) , extracorporeal membrane oxygenation , oxygenation , medicine , oxygen delivery , intensive care medicine , on demand , ards , lung , anesthesia , oxygen , computer science , materials science , chemistry , multimedia , organic chemistry , composite material
Significance The treatment of hypoxemia that is refractory to the current standard of care is time-sensitive and requires skilled caregivers and use of specialized equipment (e.g., extracorporeal membrane oxygenation). Most patients experiencing refractory hypoxemia will suffer organ dysfunction, and death is common in this cohort. Here, we describe a new strategy to stabilize and support patients using a microfluidic device that administers oxygen gas directly to the bloodstream in real time and on demand using a process that we call sequential shear-induced bubble breakup. If successful, the described technology may help to avoid or decrease the incidence of ventilator-related lung injury from refractory hypoxemia.