Open AccessEcdysone exerts biphasic control of regenerative signaling, coordinating the completion of regeneration with developmental progression
Author(s) -
Faith Karanja,
Subhshri Sahu,
Sara Weintraub,
Rajan Bhandari,
Rebecca G. Jaszczak,
Jason Sitt,
Adrian Halme
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2115017119
Subject(s) - ecdysone , regeneration (biology) , drosophila melanogaster , microbiology and biotechnology , biology , hormone , regenerative medicine , medicine , endocrinology , biochemistry , stem cell , gene
Significance For most organisms, regenerative capacity varies at different stages of development. Changes in regenerative capacity often correlate with significant changes in systemic hormone signaling. Previous studies have independently demonstrated the positive and negative effects of systemic hormone signals on the regenerative activity of tissues. Here, we report that regeneratingDrosophila melanogaster tissues produce a biphasic response to ecdysone steroid hormone levels. Below a certain threshold, ecdysone promotes regenerative activity in damaged imaginal discs. As development progresses, ecdysone levels increase above this threshold and suppress regeneration via the sequential expression of Broad transcription factor splice isoforms. Our findings describe how systemic hormone signals can direct regenerative activity to coordinate regeneration completion with developmental transitions.