Open AccessLeucine retention in lysosomes is regulated by starvation
Author(s) -
Urmi Bandyopadhyay,
Pavlina Krasimirova Todorova,
Natalya N. Pavlova,
Yuma Tada,
Craig B. Thompson,
Lydia W.S. Finley,
Michael Overholtzer
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2114912119
Subject(s) - leucine , starvation , amino acid , microbiology and biotechnology , lysosome , biochemistry , biology , gtpase , starvation response , protein biosynthesis , chemistry , enzyme , endocrinology
Significance Cells can respond to starvation by up-regulating stress responses that promote the recycling or scavenging of essential nutrients. We identify a starvation response that allows cells to store the essential amino acid leucine within lysosomes when extracellular amino acids are scarce. This “storage” response allows cells to sequester an essential amino acid in support of protein synthesis. We find that numerous essential amino acids are trafficked through lysosomes even when extracellular concentrations are high, suggesting that constitutive flux through lysosomes is related to starvation-induced storage.