Open AccessLandscape of surfaceome and endocytome in human glioma is divergent and depends on cellular spatial organization
Author(s) -
Valeria Governa,
Hugo Talbot,
Kelin Gonçalves de Oliveira,
Myriam Cerezo-Magaña,
Anna Bång-Rudenstam,
Martin Johansson,
AnnSofie Månsson,
Karin Forsberg-Nilsson,
György Markó-Varga,
Julio Enríquez Pérez,
Anna Darabi,
Johan Malmström,
Johan Bengzon,
Charlotte Welinder,
Mattias Belting
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2114456119
Subject(s) - immunotherapy , computational biology , glioma , biology , cancer immunotherapy , internalization , cancer , neuroscience , cancer research , receptor , genetics
Significance Cancer immunotherapies, including checkpoint inhibitor blocking antibodies and antibody drug conjugates, currently revolutionize cancer treatment. However, a remaining challenge is the identification of tumor surfaceome (TS) targets for the design of more rational, individualized treatments. We have developed a procedure for unbiased mapping of TS targets in glioblastoma (GBM), i.e., the most common primary malignant brain tumor that remains among the most aggressive forms of cancer, and for which attempts to find effective treatments have failed so far. The present study provides additional layers of understanding fundamental to the future development of immunotherapy strategies, as well as procedures for proteomics-based target identification aimed at a better understanding of how to harness the TS for personalized immunotherapy.