Open AccessGenetics, leadership position, and well-being: An investigation with a large-scale GWAS
Author(s) -
Zhaoli Song,
Wendong Li,
Xuye Jin,
Junbiao Ying,
Xin Zhang,
Ying Song,
Hengtong Li,
Qiao Fan
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2114271119
Subject(s) - genome wide association study , scale (ratio) , biology , phenotype , association (psychology) , genetic association , genetics , psychology , genotype , single nucleotide polymorphism , gene , geography , cartography , psychotherapist
Significance Our study presents the largest whole-genome investigation of leadership phenotypes to date. We identified genome-wide significant loci for leadership phenotypes, which are overlapped with top hits for bipolar disorder, schizophrenia, and intelligence. Our study demonstrated the polygenetic nature of leadership, the positive genetic correlations between leadership traits and a broad range of well-being indicators, and the unique association of leadership with well-being after accounting for genetic influences related to other socioeconomic status measures. Our findings offer insights into the biological underpinnings of leadership.