The hippocampus as the switchboard between perception and memory

Significance How do we adaptively switch from perceiving the external world to retrieving goal-relevant internal memories? To tackle this question, we used—in a cued-recall paradigm—direct intracranial recordings from the human hippocampus complemented by high-density scalp electroencephalography (EEG). We found that a hippocampal signal ∼500 ms after a perceptual cue marks the conversion from external (perceptual) to internal (mnemonic) representations. This sets in motion a recall cascade involving posterior parietal and medial prefrontal cortex, revealed via source-localized and time-resolved EEG alpha power. Together, these results unveil the hippocampal–cortical dynamics supporting rapid and flexible memory recall.