Monocyte-derived SDF1 supports optic nerve regeneration and alters retinal ganglion cells’ response to Pten deletion | Zendy

Lili Xie | Zendy; LingPing Cen | Zendy; Yiqing Li | Zendy; Hui-ya Gilbert | Zendy; Oleksandr Strelko | Zendy; Cynthia Berlinicke | Zendy; Mihaela Stavarache | Zendy; Madeline Ma | Zendy; Yongting Wang | Zendy; Qi Cui | Zendy; Michael G. Kaplitt | Zendy; Donald J. Zack | Zendy; Larry I. Benowitz | Zendy; Yuqin Yin | Zendy

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Monocyte-derived SDF1 supports optic nerve regeneration and alters retinal ganglion cells’ response to Pten deletion

Author(s) -

Lili Xie,

LingPing Cen,

Yiqing Li,

Hui-ya Gilbert,

Oleksandr Strelko,

Cynthia Berlinicke,

Mihaela Stavarache,

Madeline Ma,

Yongting Wang,

Qi Cui,

Michael G. Kaplitt,

Donald J. Zack,

Larry I. Benowitz,

Yuqin Yin

Publication year - 2022

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.2113751119

Subject(s) - tensin , pten , biology , microbiology and biotechnology , regeneration (biology) , pi3k/akt/mtor pathway , stromal cell , inflammation , optic nerve , retinal ganglion cell , cancer research , axon , signal transduction , immunology , neuroscience

Significance The optic nerve conveys information from retinal ganglion cells (RGCs) to visual processing areas of the brain. Although this pathway normally cannot regenerate when injured nor in degenerative diseases such as glaucoma, this failure can be partially reversed by eliciting a controlled immune reaction in the eye. We show here that the chemokine SDF1 (stromal cell–derived factor 1) is an important contributor to this phenomenon. SDF1 is produced by infiltrative monocytes and acts through its cognate receptor to enhance RGC survival, promote optic nerve regeneration, and sensitize subtypes of RGCs that normally fail to respond to a complementary treatment to exhibit robust, long-distance regeneration. These findings establish SDF1 as an important therapeutic candidate for repairing the injured optic nerve.

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