Open AccessDevelopmentally distinct CD4+Treglineages shape the CD8+T cell response to acuteListeriainfection
Author(s) -
Joseph S. Dolina,
Joey Lee,
Eugene Moore,
Jennifer L. Hope,
Donald T. Gracias,
Takaji Matsutani,
Ashu Chawla,
Jason A. Greenbaum,
Joel Linden,
Stephen P. Schoenberger
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2113329119
Subject(s) - immune system , priming (agriculture) , biology , immunology , inflammation , pathogen , cd8 , listeria monocytogenes , t cell , homeostasis , microbiology and biotechnology , genetics , bacteria , botany , germination
Significance The CD4+ Treg response following acuteListeria infection is heterogeneous and deploys two distinct modes of suppression coinciding with initial pathogen exposure and resolution of infection. This bimodal suppression of CD8+ T cells during priming and contraction is mediated by separate Treg lineages. These findings make a significant contribution to our understanding of the functional plasticity inherent within Treg s , which allows these cells to serve as a sensitive and dynamic cellular rheostat for the immune system to prevent autoimmune pathology in the face of inflammation attendant to acute infection, enable expansion of the pathogen-specific response needed to control the infection, and reestablish immune homeostasis after the threat has been contained.