Prenatal disruption of blood–brain barrier formation via cyclooxygenase activation leads to lifelong brain inflammation | Zendy

Qiuying Zhao | Zendy; Weiye Dai | Zendy; Hui Yu Chen | Zendy; Russell E. Jacobs | Zendy; Berislav V. Zloković | Zendy; Brett T. Lund | Zendy; Axel Montagne | Zendy; Alexandre Bonnin | Zendy

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Prenatal disruption of blood–brain barrier formation via cyclooxygenase activation leads to lifelong brain inflammation

Author(s) -

Qiuying Zhao,

Weiye Dai,

Hui Yu Chen,

Russell E. Jacobs,

Berislav V. Zloković,

Brett T. Lund,

Axel Montagne,

Alexandre Bonnin

Publication year - 2022

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.2113310119

Subject(s) - offspring , microglia , fetus , blood–brain barrier , inflammation , endothelial activation , in utero , neuroinflammation , biology , endocrinology , medicine , central nervous system , pregnancy , genetics

Significance This study demonstrates that maternal inflammation during pregnancy perturbs blood–brain barrier formation via cyclooxygenase activation in fetal microglia, leading to abnormal cerebrovascular function and chronic brain inflammation persisting across the offspring life span. Therefore, developmental disruption of blood–brain barrier formation could be an important etiological factor contributing to the pathology of neurodevelopmental disorders.

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