Open AccessPrenatal disruption of blood–brain barrier formation via cyclooxygenase activation leads to lifelong brain inflammation
Author(s) -
Qiuying Zhao,
Weiye Dai,
HuiYu Chen,
Russell E. Jacobs,
Berislav V. Zloković,
Brett T. Lund,
Axel Montagne,
Alexandre Bonnin
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2113310119
Subject(s) - offspring , microglia , fetus , blood–brain barrier , inflammation , endothelial activation , in utero , neuroinflammation , biology , endocrinology , medicine , central nervous system , pregnancy , genetics
Significance This study demonstrates that maternal inflammation during pregnancy perturbs blood–brain barrier formation via cyclooxygenase activation in fetal microglia, leading to abnormal cerebrovascular function and chronic brain inflammation persisting across the offspring life span. Therefore, developmental disruption of blood–brain barrier formation could be an important etiological factor contributing to the pathology of neurodevelopmental disorders.