Open AccessTransient chirality inversion during racemization of a helical cobalt(III) complex
Author(s) -
Yoko Sakata,
Shunsuke Chiba,
Shigehisa Akine
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2113237119
Subject(s) - racemization , helicity , chirality (physics) , inversion (geology) , chemistry , reagent , chemical physics , crystallography , stereochemistry , physics , organic chemistry , chiral symmetry , paleontology , particle physics , quantum mechanics , structural basin , nambu–jona lasinio model , biology , quark
Significance We first observed a transient chirality inversion on a simple unimolecular platform during the racemization of a chiral helical complex [LCo3 A 6 ]3+ , i.e., the helicity changed fromP -rich (right-handed) toM -rich (left-handed), which then racemized to aP /M equimolar mixture in spite of the absence of a reagent that could induce theM helix. This transient chirality inversion was observed only in the forward reaction, whereas the reverse reaction showed a simple monotonic change with an induction time. Consequently, theM helicity appeared only in the forward reaction. These forward and reverse reactions constitute a hysteretic cycle. Compounds showing such unique time responses would be useful for developing time-programmable switchable materials that can control the physical/chemical properties in a time-dependent manner.