Open AccessMolecular electronics sensors on a scalable semiconductor chip: A platform for single-molecule measurement of binding kinetics and enzyme activity
Author(s) -
Carl W. Fuller,
Pius S. Padayatti,
Hadi Abderrahim,
Lisa Adamiak,
Nolan Alagar,
Nagaraj Ananthapadmanabhan,
Jihye Baek,
Sarat Chinni,
Chulmin Choi,
Kevin J. Delaney,
Rich Dubielzig,
Julie Frkanec,
C. J. Gómez García,
Calvin J. Gardner,
Daniel Gebhardt,
T Geiser,
Zachariah Gutierrez,
Drew A. Hall,
Andrew Hodges,
Guangyuan Hou,
Sonal Jain,
T. P. H. Jones,
Raymond Lobaton,
Zsolt Majzik,
Allen Marte,
P. J. Mohan,
Paul W. Mola,
Paul Mudondo,
James Mullinix,
Thuan Anh Nguyen,
Frederick Ollinger,
Sarah Orr,
Yuxuan Ouyang,
Paul Pan,
Namseok Park,
David Gimeno Ruiz de Porras,
K. Venkatesh Prabhu,
Cassandra M. Reese,
Travers Ruel,
Trevor Sauerbrey,
Jaymie R. Sawyer,
Prem Sinha,
Jacky Tu,
A. G. Venkatesh,
Sushmitha VijayKumar,
Lingling Zheng,
Jin Sung-Ho,
James M. Tour,
George M. Church,
Paul W. Mola,
Barry Merriman
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2112812119
Subject(s) - biosensor , nanotechnology , aptamer , molecular binding , molecular electronics , miniaturization , oligonucleotide , chip , analyte , materials science , chemistry , computer science , molecule , dna , genetics , biology , telecommunications , biochemistry , organic chemistry
Significance Detection of molecular interactions is the foundation for many important biotechnology applications in society and industry, such as drug discovery, diagnostics, and DNA sequencing. This report describes a broadly applicable platform for detecting molecular interactions at the single-molecule scale, in real-time, label-free, and potentially highly multiplexable fashion, using single-molecule sensors on a highly scalable semiconductor sensor array chip. Such chips are both practically manufacturable in the near term, and have a durable long-term scaling roadmap, thus providing an ideal way to bring the power of modern chip technology to the broad area of biosensing. This work also realizes a 50-year-old scientific vision of integrating single molecules into electronic chips to achieve the ultimate miniaturization of electronics.