Open AccessMicroRNA networks in FLT3-ITD acute myeloid leukemia
Author(s) -
Dung Phuong Hoang,
Dandan Zhao,
Sergio Branciamore,
Davide Maestrini,
Ivan Rodriguez,
YaHuei Kuo,
Russell C. Rockne,
Samer K. Khaled,
Bin Zhang,
Le Xuan Truong Nguyen,
Guido Marcucci
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2112482119
Subject(s) - drosha , microbiology and biotechnology , myeloid leukemia , microrna , biology , protein kinase b , cancer research , phosphorylation , genetics , rna , rna interference , gene
Significance We report on a deregulatory activity on microRNA (miRNA) biogenesis by the FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) in acute myeloid leukemia. FLT3-ITD provides a divergent signal for concurrent and aberrant miR-155 up-regulation and miR-126 down-regulation via a series of miRNA–protein regulatory loops interconnected through SH2-containing inositol phosphatase 1 (SHIP1)/phosphor-protein kinase B (AKT)/Sprouty related EVH1 domain containing 1 (SPRED1) signaling. This divergent input signal eventually converges and amplifies an output signal for leukemic growth.