Open AccessThe Yun/Prohibitin complex regulates adult Drosophila intestinal stem cell proliferation through the transcription factor E2F1
Author(s) -
Hang Zhao,
Lin Shi,
Zhengran Li,
Ruiyan Kong,
Xuejing Ren,
Rui Ma,
Lemei Jia,
Meifang Ma,
Shan Lu,
Ran Xu,
Richard Binari,
Jianhua Wang,
MengQiu Dong,
Norbert Perrimon
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2111711119
Subject(s) - biology , stem cell , microbiology and biotechnology , transcription factor , prohibitin , cell growth , rna interference , progenitor cell , genetics , rna , mitochondrion , gene
Significance Stem cells maintain tissue homeostasis. We identified a factor, Yun, required for proliferation of normal and transformed intestinal stem cells in adultDrosophila . Yun acts as a scaffold to stabilize the Prohibitin (PHB) complex previously implicated in various cellular and developmental processes and diseases. The Yun/PHB complex acts downstream of EGFR/MAPK signaling and affects the levels of E2F1 to regulate intestinal stem cell proliferation. The role of the PHB complex in cell proliferation is evolutionarily conserved. Our results provide insight into the underlying mechanisms of how stem cell proliferation is properly controlled during tissue homeostasis and tumorigenesis.