Open AccessMRP5 and MRP9 play a concerted role in male reproduction and mitochondrial function
Author(s) -
Ian G. Chambers,
Praveen Kumar,
Jens Lichtenberg,
Pengcheng Wang,
Jianshi Yu,
John D. Phillips,
Maureen A. Kane,
David M. Bodine,
Iqbal Hamza
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2111617119
Subject(s) - biology , mitochondrion , reproduction , function (biology) , mitochondrial dna , genetics , physiology , bioinformatics , gene
Significance Multidrug Resistance Proteins (MRPs) are typically implicated in cancer biology. Here, we show that MRP9 and MRP5 localize to mitochondrial-associated membranes and play a concerted role in maintaining mitochondrial homeostasis and male reproductive fitness. Our work fills in significant gaps in our understanding of MRP9 and MRP5 with wider implications in male fertility. It is plausible that variants in these transporters are associated with male reproductive dysfunction.