Open AccessNeutrophil and natural killer cell imbalances prevent muscle stem cell–mediated regeneration following murine volumetric muscle loss
Author(s) -
Jacqueline Larouche,
Paula Fraczek,
Sarah J Kurpiers,
Benjamin Yang,
Carol Davis,
Jesus A. Castor-Macias,
Kaitlyn Sabin,
Shan E. Anderson,
Julia Andraca Harrer,
Matthew S. Hall,
Susan V. Brooks,
Young C. Jang,
Nick J. Willett,
Lonnie D. Shea,
Carlos A. Aguilar
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2111445119
Subject(s) - stem cell , progenitor cell , microbiology and biotechnology , regeneration (biology) , innate immune system , inflammation , fibrosis , immune system , skeletal muscle , cell , biology , pathology , medicine , immunology , anatomy , genetics
Significance Skeletal muscle is one of the largest tissues in the body and can regenerate when damaged through a population of resident muscle stem cells. A type of muscle trauma called volumetric muscle loss overwhelms the regenerative capacity of muscle stem cells and engenders fibrotic supplantation. A comparison of muscle injuries resulting in regeneration or fibrosis revealed that intercellular communication between neutrophils and natural killer cells impacts muscle stem cell-mediated repair. Perturbation of neutrophil–natural killer cell interactions resulted in a variation of healing outcomes and suggested that immunomodulatory interventions can be effective to prevent aberrant healing outcomes.