Open AccessParkinson’s disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein–induced changes in maturation and immune reactive properties
Author(s) -
Carla Azevedo,
Gabriel Teku,
Yuriy Pomeshchik,
Juan F. Reyes,
Margarita Chumarina,
Kaspar Russ,
Ekaterina Savchenko,
Anna Hammarberg,
Nuno Jorge Lamas,
Anna Collin,
Gunnar K. Gouras,
Oxana Klementieva,
Martin Hallbeck,
Ricardo Taipa,
Mauno Vihinen,
Laurent Roybon
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2111405119
Subject(s) - synucleinopathies , atrophy , parkinson's disease , alpha synuclein , immune system , neuroscience , neuroinflammation , biology , disease , immunology , medicine , pathology , inflammation , genetics
Significance Our results demonstrate the existence of early cellular pathways and network alterations in oligodendrocytes in the alpha-synucleinopathies Parkinson’s disease and multiple system atrophy. They further reveal the involvement of an immune component triggered by alpha-synuclein protein, as well as a connection between (epi)genetic changes and immune reactivity in multiple system atrophy. The knowledge generated in this study could be used to devise novel therapeutic approaches to treat synucleinopathies.