Open AccessTracing the cis-regulatory changes underlying the endometrial control of placental invasion
Author(s) -
Yasir Suhail,
Jamie Maziarz,
Ashkan Novin,
Anasuya Dighe,
Junaid Afzal,
Günter P. Wagner,
. Kshitiz
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2111256119
Subject(s) - endometrium , biology , placenta , endometrial cancer , stroma , stromal cell , metastasis , pregnancy , gene , fetus , andrology , cancer , cancer research , microbiology and biotechnology , endocrinology , genetics , immunology , immunohistochemistry , medicine
Significance Cellular invasion into adjacent tissue is observed in pregnancy, where the fetal placenta invades the mother’s endometrium, and in cancer, where tumor dissemination into stroma is a necessary step before metastasis. The behavior of the surrounding tissue, and its role in either facilitating or resisting this invasion, has not been as deeply studied as the role of the invading cells. The degree of placental invasion into the endometrium varies significantly between different eutherian mammals. Having previously shown that the endometrium of different mammals is significantly responsible for these differences, we identify cis-regulatory elements underlying these differences and show the functional effect of the corresponding transcriptional factors in regulating invasion.