Open AccessReplication is the key barrier during the dual-host adaptation of mosquito-borne flaviviruses
Author(s) -
Yanan Zhang,
Dening Liang,
Fei Yuan,
Yiran Yan,
Zuoshu Wang,
Pan Liu,
Yu Qian,
Xing Zhang,
Xiangxi Wang,
Ai Zheng
Publication year - 2022
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2110491119
Subject(s) - biology , host (biology) , vertebrate , virology , viral replication , adaptation (eye) , host adaptation , virus , untranslated region , genetics , rna , gene , virulence , neuroscience
Significance Most viruses have a relatively narrow host range. In contrast, vector-borne flaviviruses, such as dengue virus and Zika virus, maintain their transmission cycle between arthropods and vertebrates, belonging to different phyla. How do these viruses adapt to the distinct cellular environments of two phyla? By comparing the single-host insect--specific flavivirus and dual-host Zika virus, we identified three key molecular factors that determine MBF host tropism. This study will greatly increase the understanding of entry, replication, and cross-species evolution of mosquito-borne flaviviruses.