Open AccessAnatomy of an extensively drug-resistant Klebsiella pneumoniae outbreak in Tuscany, Italy
Author(s) -
Melissa J. Martin,
Brendan W. Corey,
Filomena Sannio,
Lindsey R. Hall,
Ulrike MacDonald,
Brendan T. Jones,
Emma G. Mills,
Casey Harless,
Jason Stam,
Rosslyn Maybank,
Yoon I. Kwak,
Katharina Schaufler,
Karsten Becker,
Nils–Olaf Hübner,
Stefania Cresti,
Giacinta Tordini,
Marcello Valassina,
Maria Grazia Cusi,
Jason W. Bennett,
Thomas A. Russo,
Patrick T. McGann,
François Lebreton,
Jean Denis Docquier
Publication year - 2021
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2110227118
Subject(s) - biology , klebsiella pneumoniae , tigecycline , plasmid , outbreak , colistin , multilocus sequence typing , microbiology and biotechnology , fosfomycin , virology , virulence , antibiotics , gene , genetics , escherichia coli , genotype
Significance Carbapenem-resistantKlebsiella pneumoniae belongs to the “critical-priority” tier of bacterial pathogens as identified by the World Health Organization. Emerging “high-risk” lineages are responsible for difficult-to-treat, hospital-acquired infections and outbreaks around the globe. By integrating genomic and epidemiological data for isolates collected over 20 mo, this study revealed both the high, regional prevalence and the rapid spread, within a single hospital, ofK. pneumoniae ST-147 in Italy. Besides resistance to nearly all antibiotics, this lineage carried a hybrid plasmid harboring a set of biomarker genes previously linked to hypervirulence. Convergence of resistance and virulence determinants is a major concern and these findings highlight the need for robust, global surveillance to monitor the emergence of high-riskK. pneumoniae .