Electrochemical borylation of carboxylic acids | Zendy

Lisa M. Barton | Zendy; Longrui Chen | Zendy; Donna G. Blackmond | Zendy; Phil S. Baran | Zendy

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Electrochemical borylation of carboxylic acids

Author(s) -

Lisa M. Barton,

Longrui Chen,

Donna G. Blackmond,

Phil S. Baran

Publication year - 2021

Publication title -

proceedings of the national academy of sciences

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.2109408118

Subject(s) - borylation , natural product , modular design , electrochemistry , substrate (aquarium) , scalability , combinatorial chemistry , cyclopropane , scope (computer science) , carboxylic acid , chemistry , reagent , alkyl , organic chemistry , computer science , nanotechnology , materials science , electrode , ecology , biology , programming language , database , ring (chemistry) , aryl

A simple electrochemically mediated method for the conversion of alkyl carboxylic acids to their borylated congeners is presented. This protocol features an undivided cell setup with inexpensive carbon-based electrodes and exhibits a broad substrate scope and scalability in both flow and batch reactors. The use of this method in challenging contexts is exemplified with a modular formal synthesis of jawsamycin, a natural product harboring five cyclopropane rings.

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